2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

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Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123657
    RXP 407
    		Inhibitor
    RXP 407 is a potent and selective Angiotensin-converting Enzyme (ACE) inhibitor with a Ki of 12nM.
    RXP 407
  • HY-125341
    Microginin 527
    Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds.
    Microginin 527
  • HY-P10791
    YYLLVR
    		Inhibitor
    YYLLVR is an angiotensin-converting enzyme (ACE) inhibitory peptide with an inhibitory rate of 89.10%. YYLLVR has a lower binding energy for ACE of -35.98 kcal/mol. YYLLVR can be used in the study of hypertensive diseases.
    YYLLVR
  • HY-N4090R
    Vicenin 3 (Standard)
    		Inhibitor
    Vicenin 3 (Standard) is the analytical standard of Vicenin 3. This product is intended for research and analytical applications. Vicenin 3 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=46.91 μM) from the aerial parts of Desmodium styracifolium.
    Vicenin 3 (Standard)
  • HY-P4546
    Abz-Ser-Pro-3-nitro-Tyr
    Abz-Ser-Pro-3-nitro-Tyr is the substrate of ACE2 (angiotensin-converting enzyme-2).
    Abz-Ser-Pro-3-nitro-Tyr
  • HY-110066R
    (Z)-Guggulsterone (Standard)
    		Inhibitor
    (Z)-Guggulsterone (Standard) is the analytical standard of (Z)-Guggulsterone. This product is intended for research and analytical applications. (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection.
    (Z)-Guggulsterone (Standard)
  • HY-P4654
    H-Tyr-Lys-OH
    H-Tyr-Lys-OH is a dipeptide that can be used as a biomarker for AJH-1. H-Tyr-Lys-OH has a good binding affinity to angiotensin converting enzyme (ACE).
    H-Tyr-Lys-OH
  • HY-109592S
    Imidaprilate-d5
    		Inhibitor
    Imidaprilate-d5 is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.
    Imidaprilate-d<sub>5</sub>
  • HY-P4471
    p-Hydroxyhippuryl-His-Leu
    p-Hydroxyhippuryl-His-Leu is a peptide substrate of angiotensin-converting enzyme (ACE).
    p-Hydroxyhippuryl-His-Leu
  • HY-A0117
    Temocaprilat
    		Inhibitor
    Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation.
    Temocaprilat
  • HY-113748
    Rev 6207 free base
    		Inhibitor
    Rev 6207 (free base) is a potent non-thiol angiotensin I converting enzyme inhibitor. Rev 6207 (free base) has comparable antihypertensive activity to Enalapril (HY-B0331) in awake monkeys with high renin activity and can be used in the study of hypertensive diseases.
    Rev 6207 free base
  • HY-122032
    A 58365A
    		Inhibitor
    A 58365A is a potent angiotensin converting enzyme (ACE) inhibitor.
    A 58365A
  • HY-118164
    Ro 31-8472
    		Inhibitor
    Ro 31-8472 is a Cilazapril (HY-A0043) derivative. Ro 31-8472 is an angiotensin-converting enzyme (ACE) inhibitor.
    Ro 31-8472
  • HY-B0331AR
    Enalapril (maleate) (Standard)
    		Inhibitor
    Enalapril (maleate) (Standard) is the analytical standard of Enalapril (maleate). This product is intended for research and analytical applications. Enalapril (MK-421) maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.
    Enalapril (maleate) (Standard)
  • HY-A0115S2
    Ramiprilat-d4 hydrochloride
    		Inhibitor
    Ramiprilat-d4 hydrochloride is deuterated labeled Ramiprilat (HY-A0115). Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research.
    Ramiprilat-d<sub>4</sub> hydrochloride
  • HY-107339R
    Deserpidine (Standard)
    		Inhibitor
    Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.
    Deserpidine (Standard)
  • HY-B0130AS
    Perindopril-d3 erbumine
    Perindopril-d3 (erbumine) is deuterated labeled Perindopril (erbumine) (HY-B0130A). Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NF-κB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
    Perindopril-d<sub>3</sub> erbumine
  • HY-123068R
    Captopril disulfide (Standard)
    		Inhibitor
    Captopril disulfide (Standard) is the analytical standard of Captopril disulfide. This product is intended for research and analytical applications. Captopril disulfide is a metabolite of Captopril with antihypertensive activity.
    Captopril disulfide (Standard)
  • HY-123381
    Gemopatrilat
    		Inhibitor
    Gemopatrilat (BMS-189921) is an orally active vasopeptidase inhibitor with IC50 value of 12 nM. Gemopatrilat can be used in studies of hypertension and congestive heart failure.
    Gemopatrilat
  • HY-101733
    Zabicipril hydrochloride
    		Inhibitor
    Zabicipril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Zabicipril hydrochloride can be used for the study of blood pressure and peripheral arterial insufficiency.
    Zabicipril hydrochloride
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity